cyaA

Bifunctional hemolysin/adenylate cyclase is a protein that in B. pertussis (the bacteria that causes whooping cough) is encoded by the cyaA gene. This protein in turn is cleaved into a calmodulin-sensitive adenylate cyclase (cyaA–ACD) and hemolysin. Both are virulence factors facilitating respiratory tract colonization by B. pertussis. The cyaA–ACD binds to a M2 integrin cell surface receptor and inserts its N-terminal adenylyl cyclase domain into the cytosol. After binding to calmodulin, cyaA–ACD catalyzes the cyclization of AMP into cAMP. This catalysis raises the intracellular concentration of cAMP to toxic levels.

单词	cyaA
释义	cyaA 英语百科 cyaA Bifunctional hemolysin/adenylate cyclase is a protein that in B. pertussis (the bacteria that causes whooping cough) is encoded by the cyaA gene. This protein in turn is cleaved into a calmodulin-sensitive adenylate cyclase (cyaA–ACD) and hemolysin. Both are virulence factors facilitating respiratory tract colonization by B. pertussis. The cyaA–ACD binds to a M2 integrin cell surface receptor and inserts its N-terminal adenylyl cyclase domain into the cytosol. After binding to calmodulin, cyaA–ACD catalyzes the cyclization of AMP into cAMP. This catalysis raises the intracellular concentration of cAMP to toxic levels.
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