开普吉拉多县（Cape Girardeau County, Missouri）是美国密苏里州东南部的一个县，东隔密西西比河与伊利诺伊州相望。面积1,518平方公里。根据美国2000年人口普查，共有人口68,693。县治杰克逊。

成立于1818年，县名来自一块面临密西西比河的礁石，以在当地开设商端口的法**人Jean Baptiste de Girardot命名。

Cape Girardeau County is a county located in the southeastern part of the U.S. state of Missouri; its eastern border is formed by the Mississippi River. As of the 2010 U.S. Census, the population was 75,674. The county seat is Jackson, the first city in the US to be named in honor of President Andrew Jackson. Officially organized on October 1, 1812, the county is named after Ensign Sieur Jean Baptiste de Giradot, an official of the French colonial years. The "cape" in the county's name is named after a former promontory rock overlooking the Mississippi River; this feature was demolished during railroad construction.