3-hydroxybutyrate dehydrogenase

In enzymology, a 3-hydroxybutyrate dehydrogenase (EC1.1.1.30) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are (R)-3-hydroxybutanoate and NAD, whereas its three products are acetoacetate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-3-hydroxybutanoate:NAD oxidoreductase. Other names in common use include NAD-beta-hydroxybutyrate dehydrogenase, hydroxybutyrate oxidoreductase, beta-hydroxybutyrate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, D-3-hydroxybutyrate dehydrogenase, D-(–)-3-hydroxybutyrate dehydrogenase, beta-hydroxybutyric acid dehydrogenase, 3-D-hydroxybutyrate dehydrogenase, and beta-hydroxybutyric dehydrogenase. This enzyme participates in synthesis and degradation of ketone bodies and butanoate metabolism.