太空望远镜科学研究所（Space Telescope Science Institute，缩写为STScI） 是哈伯太空望远镜（1990年进入轨道） 和詹姆斯·韦伯太空望远镜（预计于2014年发射升空） 的科学控制中心。STScI位于美国马里兰州巴尔的摩市的约翰霍普金斯大学，是于1981年成立的以社区为基础的科学中心，由大学天文研究协会接受美国国家航空暨太空总署的委托负责管理和运作。目前，除了持续运行哈伯太空望远镜的科学任务和准备韦伯太空望远镜的经营管理和科学研究计划之外，STScI还管理和运作太空望远镜文件多任务任务 （Multi-mission Archive at Space Telescope，MAST）、克卜勒任务的数据管理中心，和以太空为基础的天文观测和基于太空中其他活动而受益的数种专门知识和基础设施的支持中心。STScI的资金大部分来自NASA的戈达德太空飞行中心，但是少部分来自NASA的艾美斯研究中心、喷射推进实验室和欧洲太空总署（ESA）。STScI的工作人员包括科学家 （大多数市天文学家和天文物理学家）、软件工程师、数据管理翰望远镜操作人员，还有教育人员、公共关系专家、行政和业务支持人员。STScI大约有100位博士学位的工作者，其中有15位是欧洲太空总署配置在哈伯太空望远镜专案的人员。STScI的全部工作人员大约有450人。

The Space Telescope Science Institute (STSCI) is the science operations center for the Hubble Space Telescope and for the James Webb Space Telescope (JWST; scheduled to be launched in 2018). STSCI is located on the Johns Hopkins University Homewood Campus in Baltimore, Maryland and was established in 1981 as a community-based science center that is operated for NASA by the Association of Universities for Research in Astronomy (AURA). Today, in addition to performing continuing science operations of HST and preparing for scientific exploration with JWST, STScI manages and operates the Mikulski Archive for Space Telescopes (MAST), the Data Management Center for the Kepler mission and a number of other activities benefiting from its expertise in and infrastructure for supporting the operations of space-based astronomical observatories. Most of the funding for STScI activities comes from contracts with NASA's Goddard Space Flight Center but there are smaller activities funded by NASA's Ames Research Center, NASA’s Jet Propulsion Laboratory, and the European Space Agency (ESA). The staff at STScI consists of scientists (mostly astronomers and astrophysicists), software engineers, data management and telescope operations personnel, education and public outreach experts, and administrative and business support personnel. There are approximately 100 Ph.D. scientists working at STScI, 15 of which are ESA staff who are on assignment to the HST project. The total STScI staff consists of about 450 people.