| 单词 | demethylate |
| 释义 |
demethylate
英汉-汉英词典
n. 脱甲基
词组 | 习惯用语
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网络短语:demethylate 脱甲基
原声例句
经济学人-科技 Drugs that demethylate DNA are under development, but are still some way from approval—and, in any case, interfering with epigenetics, which is a widespread mechanism of gene regulation, is a drastic approach. 让DNA反甲基化的药物还在研发中，并且还未通过临床证明。另外，外因遗传是基因调控的常见手段。从任何角度来说，干预外因遗传都是一种极端激进的做法。
英语百科
Demethylating agentDemethylating agents are compounds that can inhibit methylation, resulting in the expression of the previously hypermethylated silenced genes (see Methylation#Cancer for more detail). Cytidine analogs such as 5-azacytidine (azacitidine) and 5-azadeoxycytidine (decitabine) are the most commonly used demethylating agents . These compounds work by binding to the enzymes that catalyse the methylation reaction, DNA methyltransferases; and titrate out these enzymes. Both compounds have been approved in the treatment of Myelodysplastic syndrome (MDS) by Food and Drug Administration (FDA) in United States. Azacitidine and decitabine are marketed as Vidaza and Dacogen respectively. Azacitidine is the first drug to be approved by FDA for treating MDS and has been given orphan drug status. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. |
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