In some cases, Cushing syndrome results from a pituitary adenoma making excess ACTH, and in those situations it's called Cushing disease.

在某些病例中，库欣综合征是由垂体腺瘤制造过多促肾上腺皮质激素导致的；在这种情况下，它被称作库欣病。

In Cushing syndrome, cortisol levels are constantly higher than normal, so its effects are exaggerated.

库欣综合征患者的皮质醇水平比正常值高，所以它的作用会放大。

All right as a quick recap, Cushing syndrome is any condition or situation that causes increased levels of cortisol.

总结一下 好，快速回顾一下！库欣综合征是一种由皮质醇水平升高而导致的疾病。

Treatment of Cushing syndrome depends on the underlying cause.

库欣综合征的治疗由根本病因决定。

There are also diseases that can cause osteoporosis like Turner syndrome, hyperprolactinemia, Klinefelter syndrome, Cushing syndrome, and diabetes mellitus.

也有一些疾病会导致骨质疏松，比如Turner综合征、高催乳素血症、先天性睾丸发育不全综合征、皮质醇增多症以及糖尿病。

In addition to taking exogenous steroid medications, Cushing syndrome can also result from increased levels of endogenous cortisol.

除了服用外源性类固醇药物外，内源性皮质醇的升高也会导致库欣综合征。

The net result, though, is still abnormally high levels of cortisol, and that causes Cushing syndrome to develop.

然而最终的结果还是异常高水平的皮质醇引发库欣综合征。

Regardless of the cause, the symptoms of Cushing syndrome are directly related to the effects of excess cortisol on its various target tissues.

不论是什么病因，库欣综合征的症状与过量皮质醇对各种靶器官的影响有直接关系。

If Cushing syndrome is due to a pituitary adenoma - like in Cushing disease - then surgical excision of the adenoma may be needed.

如果库欣综合征是由于垂体腺瘤导致，比如库欣病，那可能需要手术移除腺瘤。

Cushing syndrome can happen because of exogenous cortisol meaning that it comes from outside usually in the form of medications, or because of endogenous cortisol - meaning that the excess cortisol is made by the body.

库欣综合征可以由外源性皮质醇导致，就是说它是从外界来的，一般由药物摄取；也可以由内源性皮质醇导致，也就是身体本身制造了过多的皮质醇。

Even though this results in less endogenous cortisol production, it still doesn't quite compensate for the huge levels of exogenous cortisol, and that causes Cushing syndrome to develop.

即便造成了内源皮质醇生成减少，这仍不能代偿高水平的外源性皮质醇，并会引发库欣综合征。

Normally that should cause a decrease in serum cortisol levels, but if Cushing syndrome is caused by endogenous cortisol production, then the serum cortisol levels should remain unchanged.

一般来说，这会导致血清皮质醇水平降低，但如果库欣综合征是由内源性皮质醇制造产生的，那么血清皮质醇水平应该保持不变。

Another common cause of endogenous Cushing syndrome is tumors of the adrenal glands that make excess cortisol - like adrenal adenomas, which are benign tumors, and adrenal carcinomas, which are malignant tumors.

另一种常见的内源性库欣综合征的原因是肾上腺肿瘤导致过多的皮质醇分泌，比如肾上腺腺瘤，一种良性肿瘤，还有肾上腺癌，一种恶性肿瘤。

The majority of cases of Cushing syndrome occur in individuals using exogenous steroid medications over a long period of time - often to treat autoimmune and inflammatory disorders, like asthma or rheumatoid arthritis.

大多数个体库欣综合征的病例是由于长期服用外源性类固醇药物，它们经常被用来治疗自身免疫性和炎症性疾病，比如哮喘或类风湿性关节炎。

Diagnosis of Cushing syndrome is initially based on measuring the free, or unbound cortisol in a 24-hour urine sample, in order to assess the total amount of cortisol excreted in the urine over a 24-hour period.

库欣综合征最开始的诊断时基于测量24小时尿液样品里的游离皮质醇，以计算过去24小时内排出体外的尿液中皮质醇的总量。