Città di Castello (Italian pronunciation: [tʃitˈta ddi kaˈstɛllo]) is a city and comune in the province of Perugia, in the northern part of the Umbria region of Italy. It is situated on a slope of the Apennines, on the flood plain of the river Tiber. The city is 56 km (35 mi) north of Perugia and 104 km (65 mi) south of Cesena on the S3bis. It is connected to the A1 highway by the SS 73 from Arezzo (17 mi). Città di Castello has an exclave named Monte Ruperto within Marche.