电脉冲化疗是一种通过施加局部电脉冲，增加细胞通透性，将通常情况下无法进入细胞内部的药物送入细胞内，从而达到杀死癌细胞目的的治疗癌症的疗法。配合博莱霉素和顺铂使用电脉冲化疗治疗皮内和皮下肿瘤的研究已经进入临床阶段。第一次伯莱霉素电脉冲化疗于1991年在法国Gustave Roussy研究所实现，第一次顺铂电脉冲化疗则于1995年在斯洛文尼亚卢布尔雅那肿瘤研究所实现。其后，来自全球多个国家（爱尔兰、澳洲、奥地利、比利时、保加利亚、丹麦、德国、法国、美国、墨西哥、尼加瓜拉、波兰、葡萄牙、日本、瑞士、斯洛文尼亚、西班牙、希腊、匈牙利、意大利、英国）的4000多名患者接受了电脉冲化疗。最近，为了治疗体内肿瘤，开发了通过外科手术、内窥镜、皮下穿刺等方法到达患处的新的电脉冲化疗方法。

Electrochemotherapy is a type of chemotherapy that allows delivery of non-permeant drugs to the cell interior. It is based on the local application of short and intense electric pulses that transiently permeabilize the cell membrane, thus allowing transport of molecules otherwise not permitted by the membrane. Applications for treatment of cutaneous and subcutaneous tumors have reached clinical use by utilizing drugs such as bleomycin or cisplatin). Electrochemotherapy with bleomycin was used to treat a patient for the first time in 1991 at the Institute Gustave Roussy in France, while electrochemotherapy with cisplatin was used to treat for the first time in 1995 at the Institute of Oncology, Ljubljana, Slovenia. Since then, more than 4000 patients were treated with electrochemotherapy all over the world (Australia, Austria, Belgium, Bulgaria, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Mexico, Nicaragua, Poland, Portugal, Slovenia, Spain, Sweden, UK, USA). Recently, new electrochemotherapy modalities have been developed for treatment of internal tumors using surgical procedures, endoscopic routes, or percutaneous approaches to gain access to the treatment area.