蓝色基因（英语：Blue Gene）是一个由IBM主导的电脑系统结构计划，用来制造一系列的超级电脑，已达到千兆（=10）每秒的浮点运算的能力。

本计划制造了三代超级计算机，分别是Blue Gene/L、Blue Gene/P和Blue Gene/Q。

截至2012年6月，世界上运算速度最快的超级电脑——Sequoia（红杉），即是由IBM为美国劳伦斯‧利弗莫尔国家实验室研发的Blue Gene/Q，它内含1572864个处理器，每秒能完成16千兆次浮点运算（16PFLOPS）。

Blue Gene is an IBM project aimed at designing supercomputers that can reach operating speeds in the PFLOPS (petaFLOPS) range, with low power consumption.

The project created three generations of supercomputers, Blue Gene/L, Blue Gene/P, and Blue Gene/Q. Blue Gene systems have often led the TOP500 and Green500 rankings of the most powerful and most power efficient supercomputers, respectively. Blue Gene systems have also consistently scored top positions in the Graph500 list. The project was awarded the 2009 National Medal of Technology and Innovation.