美国中央司令部（英语：United States Central Command，缩写：「USCENTCOM」）是美国国防部下的一个战区级联合作战司令部，创建于1983年，其前身为快速部署联合任务部队（Rapid Deployment Joint Task Force，缩写：RDJTF）。

中央司令部的负责范围包括中东、北非和中亚的国家，其中最著名的是阿富汗与伊拉克。中央司令部作为美军活跃的存在而参与了许多军事行动，包括波斯湾战争、阿富汗战争和伊拉克战争。中央司令部的军队近期主要布署于伊拉克和阿富汗一带运行战斗任务，还在科威特、巴林、卡塔尔、阿拉伯联合酋长国、阿曼、巴基斯坦等国设有基地，中亚国家亦提供支持。先前，中央司令部军队也曾布署于约旦和沙特阿拉伯，尽管后者国内并无驻扎实质的武装部队。现任司令为约瑟夫·沃特尔三世上将。

The United States Central Command (USCENTCOM or CENTCOM) is a theater-level Unified Combatant Command of the U.S. Department of Defense, established in 1983, taking over the 1980 Rapid Deployment Joint Task Force (RDJTF) responsibilities.

The CENTCOM Area of Responsibility (AOR) includes countries in the Middle East, North Africa, and Central Asia, most notably Afghanistan and Iraq. CENTCOM has been the main American presence in many military operations, including the Persian Gulf War (Operation Desert Storm, 1991), the War in Afghanistan (Operation Enduring Freedom, 2001–2014), and the Iraq War (Operation Iraqi Freedom, 2003-2011). As of 2015 CENTCOM forces are deployed primarily in Afghanistan (Operation Resolute Support, 2015–Present) and Iraq (Operation Inherent Resolve, 2014–present) in supporting and advise and assist roles.