Theca lutein cysts are more likely to develop when there's more hCG than usual, like when there are multiple fetuses, or with gestational trophoblastic disease, where tumours made up of placental cells causes higher than normal hCG levels.

卵泡膜黄素囊肿一般发生于hCG较正常高的情况，如多胎妊娠或患有妊娠滋养细胞疾病时；该病中由胎盘细胞组成的肿瘤会导致hCG较高。