音猬因子（Sonic hedgehog，SHH）是5种刺猬（Hedgehog，HH）因子（其他四种是沙漠刺猬因子，DHH、印度刺猬因子，IHH、Echidna Hedgehog，EHH和Tiggywinkle Hedgehog，TwHH）中的一种。 刺猬因子是重要的信号传导途径。而音猬因子则是刺猬信号传导途径中研究最透彻的配体，这种因子作为重要的形态发生素（Morphogen），在调节脊椎动物器官发育中起关键作用，比如它决定四肢以及脑脊髓正中线的形成。音猬因子在成年个体中也很重要，它控制成年体细胞的分裂。音猬因子的失控将导致癌症。

Sonic hedgehog is a protein that in humans is encoded by the SHH ("sonic hedgehog") gene. Both the gene and the protein may also be found notated alternatively as "Shh".

Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in the development of some cancers.