Type II topoisomerase

（重定向自Topoisomerase II）

Structure of the 42 KDa fragment of the N-terminal ATPase and transducer domains of DNA gyrase homologous to all other type IIA topoisomerases.

Structure of yeast topoisomerase II bound to a doubly nicked 34-mer duplex DNA (PDB ID =2RGR). The Toprim fold is colored cyan; the DNA is colored orange; the HTH is colored magenta; and the C-gate is colored purple. Notice that the DNA is bent by ~160 degrees through an invariant isoleucine (Ile833 in yeast).

Structure of topo VI (PDB ID =2Q2E). Monomers are colored differently. The N-terminal ATPase domain lies on the top of the molecule, forming the DNA gate, while the DNA gate lies on the bottom.

Type II topoisomerases cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use the hydrolysis of ATP, unlike Type I topoisomerase. In this process, these enzymes change the linking number of circular DNA by ±2.

单词	Topoisomerase II
释义	Topoisomerase II 英语百科 Type II topoisomerase （重定向自Topoisomerase II） Type II topoisomerases cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use the hydrolysis of ATP, unlike Type I topoisomerase. In this process, these enzymes change the linking number of circular DNA by ±2.
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