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单词 Tametraline
释义

Tametraline

英语百科

Tametraline

Preparation of Tametraline: U.S. Patent 4,045,488 Reinhard Sarges; Pfizer Inc.
one-pot synthesis of 1-amino-4-aryl-tetralin derivatives by the CAN-induced cyclodimerization of various styrenes in acetonitrile and acrylonitrile

Tametraline (CP-24,441) is the parent of a series of chemical compounds investigated at Pfizer that eventually led to the development of sertraline (CP-51,974-1).

Sertraline has been called "3,4-dichloro tametraline". This is correct but it is an oversimplification in the sense that sertraline is the SS isomer whereas tametraline is the 1R,4S stereoisomer.

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更新时间:2025/6/17 18:19:09