Acifran

Acifran is a niacin receptor agonist.

It is synthesized from acetophenone and the anion of 1-methyl-2,6-dithiolane (2) (prepared using BuLi). The latter is a reversed polarity version of acetaldehyde (Umpolung) whose condensation with 1 produces tertiary alcohol 3 by carbonyl addition. Acid-catalyzed dithiolane exchange with pyruvate leads to α-hydroxyketone 4. This last undergoes base-catalyzed oxylation on the methyl ketone moiety and cyclodehydration and ester hydrolysis to produce acifran 5.

单词	Acifran
释义	Acifran 英语百科 Acifran Acifran is a niacin receptor agonist. It is synthesized from acetophenone and the anion of 1-methyl-2,6-dithiolane (2) (prepared using BuLi). The latter is a reversed polarity version of acetaldehyde (Umpolung) whose condensation with 1 produces tertiary alcohol 3 by carbonyl addition. Acid-catalyzed dithiolane exchange with pyruvate leads to α-hydroxyketone 4. This last undergoes base-catalyzed oxylation on the methyl ketone moiety and cyclodehydration and ester hydrolysis to produce acifran 5.
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