生精小管（英语：seminiferous tubule； 拉丁语：tubuli seminiferi；又称曲细精管）位于睾丸，是减数分裂特定位置并继而制造配子（即精子）。

生精小管的上皮由支持细胞或称塞尔托利氏细胞组成，这种细胞呈高桶形排列于生精小管之上。

位于塞尔托利氏细胞之间的是生精细胞，后者通过减数分裂分化为精子。

有两种类型的生精小管：曲生精小管与直生精小管，前者位于侧边而后者位于中侧以形成出睾丸的出口信道。

生精小管是由原始生殖腺索发生而成的，髓索发育为生精小管且次级性索退化。腺索由生殖腺嵴发生形成。

Seminiferous tubules are located within the testes, and are the specific location of meiosis, and the subsequent creation of male gametes, namely spermatozoa.

The epithelium of the tubule consists of a type of sustentacular cells known as Sertoli cells, which are tall, columnar type cells that line the tubule.