塞利姆二世（英语：Selim II，1524年5月28日－1574年12月12日）是奥斯曼帝国的苏丹，自1566年起在位直至逝世。他是苏莱曼一世及其妻许蕾姆苏丹之子（金发碧眼塞利姆）。

塞利姆二世登基后，沉迷酒色，因此被称为「酒鬼塞利姆」。国政大多由他的大宰相（麦何密·索库鲁Mehmed Sokollu）负责。1568年2月17日，帝国与哈布斯堡王朝的神圣罗马皇帝马克西米连二世订立条约，后者同意每年向奥斯曼「送赠」3万个金币，及实际上承认奥斯曼对摩尔达维亚及瓦拉奇的主权。

奥斯曼帝国面对俄罗斯帝国却没有那么顺利。君士坦丁堡当局打算以运河连接伏尔加河及顿河，联系中亚的突厥人。在1569年夏天，一支由精锐土耳其新军及骑兵组成的大军前往围困阿斯特拉罕及开始运河工程，同时一支舰队围困亚速海。可是阿斯特拉罕的俄罗斯守军击退了围城者，另外15000俄国援军击溃了建造运河的工人及保护他们的鞑靼军，最后奥斯曼的舰队也被风暴摧毁。1570年初，俄国沙皇伊凡四世与奥斯曼达成和约。

Selim II (Ottoman Turkish: سليم ثانى Selīm-i sānī, Turkish:II.Selim; 28 May 1524 – 12 December/15 December 1574), also known as "Selim the Sot (Mest)" in west and as "Sarı Selim" (Selim the Blond) in east, was the Sultan of the Ottoman Empire from 1566 until his death in 1574. He was a son of Suleiman the Magnificent and Haseki Hürrem Sultan. Selim had been an unlikely candidate for the throne until his brother Mehmed died of smallpox, his brother Mustafa was strangled to death by his father, and his brother Bayezid was killed in a coordinated effort between him and his father. His reign is generally marked as the start of a decline following the excellent reign of his father.