脱线喜剧（英语：screwball comedy）是一种美国喜剧电影类型，流行于大萧条时期，在1930年代起源，繁荣至1940年代早期。该类型的很多次要特征类似于黑色电影，但不同之处在于有一个女性角色在和男主角的关系中占主导地位，挑战他的男子气概。男女主角陷于幽默搞笑的两性斗争之中，这对于当时的好莱坞和观众来说是新颖的主题。其他元素包括快节奏的妙语连珠的对话、滑稽的情形、逃避现实的主题，以及涉及爱情和婚姻的情节。脱线喜剧经常描绘社会阶层之间的冲突，如在《一夜风流》（1934）和《我的高德弗里》（1936）中。

The screwball comedy is principally an American genre of comedy film that became popular during the Great Depression, originating in the early 1930s and thriving until the early 1940s. Many secondary characteristics of this genre are similar to the film noir, but it distinguishes itself for being characterized by a female that dominates the relationship with the male central character, whose masculinity is challenged. The two engage in a humorous battle of the sexes, which was a new theme for Hollywood and audiences at the time. Other elements are fast-paced repartee, farcical situations, escapist themes, and plot lines involving courtship and marriage. Screwball comedies often depict social classes in conflict, as in It Happened One Night (1934) and My Man Godfrey (1936). Some comic plays are also described as screwball comedies.