Santa Fé de Minas is a Brazilian municipality located in the north of the state of Minas Gerais. In 2007 the population was 4,034 in a total area of 2,916 km². It became a municipality in 1962.

Santa Fé de Minas is located about 130 km. northwest of the nearest major population center, Pirapora at an elevation of 493 meters. Neighboring municipalities are: São Romão, Buritizeiro, Brasilândia de Minas, and Bonfinópolis de Minas. It is part of the statistical microregion of Pirapora.