萨克拉门托河（Sacramento River）是美国加利福尼亚州最长的河流。

该河发源于卡斯克德山脉的沙斯特山附近，全长382英里。该河由发源地开始流向西南，穿过位于太平洋海岸山脉和内华达山脉之间的加利福尼亚中央谷地北部，然后在与美国河汇合的地方不远，它就连同圣华金河形成萨克拉门托河三角洲，然后注入旧金山湾北部。其主要支流为皮特河、番泽河、梅克劳德河以及美国河。其中皮特河最长，但番泽河与美国河的流量更大。

人工运河使该河自旧金山湾入海口以上180英里都可以航行，远洋轮可一直上溯至萨克拉门托。开辟航道后，有时会发现一些海洋生物如灰鲸和海狮等误入河中觅食或寻求庇护，无法重返太平洋。

The Sacramento River is the principal river of Northern California in the United States, and is the largest river in California. Rising in the Klamath Mountains, the river flows south for 445 miles (716 km) before reaching the Sacramento–San Joaquin River Delta and San Francisco Bay. The river drains about 27,500 square miles (71,000 km) in 19 California counties, mostly within a region bounded by the Coast Ranges and Sierra Nevada known as the Sacramento Valley, but also extending as far as the volcanic plateaus of Northeastern California. Historically, its watershed has reached farther, as far north as south-central Oregon where the now, primarily, endorheic (closed) Goose Lake rarely experiences southerly outflow into the Pit River, the most northerly tributary of the Sacramento.