The activation of complement causes inflammation and destruction of the muscle cells and reduces the amount of acetylcholine receptors on the surface.

补体激活引起炎症反应，破坏肌肉细胞，减少其表面的乙酰胆碱受体数量。

It's possible that this is because helper T cells, which originate in the thymus, help B cells make antibodies to the acetylcholine receptor.

这可能是因为起源于胸腺的T细胞，帮助B细胞产生ACh受体抗体。

Alright, so in this case, the patient's B cells inappropriately make antibodies that bind to nicotinic acetylcholine receptors on the muscle cells.

好了，在这种情况下，患者的B细胞产生了错误的抗体，该抗体和肌肉细胞中N胆碱受体相结合。

This is where Antimuscarinic agents come into play by blocking the muscarinic acetylcholine receptors and cholinergic nerve activity.

这就是抗真菌剂通过阻断毒蕈碱乙酰胆碱发挥作用的地方受体和胆碱能神经活动。

Myasthenia gravis is a type II hypersensitivity disorder where the body produces antibodies that most commonly target nicotinic acetylcholine receptors on the surface of muscle cells.

重症肌无力是一种II型超敏反应，身体产生抗体，常见靶点为肌肉细胞表面的N胆碱受体抗体。

First you've got your motor neurons that release the neurotransmitter acetylcholine at the neuromuscular junction, which then binds to nicotinic acetylcholine receptors on muscle cell membranes.

首先，你的运动神经元在神经肌肉接头处释放神经递质乙酰胆碱（ACh），然后与肌肉细胞膜上的N胆碱受体相结合。

COREY ALLARD: They didn't resemble known sensory  receptors instead they're most closely related to a family of receptors called  nicotinic acetylcholine receptors.

COREY ALLARD：它们不像已知的感觉受体，相反，它们与称为烟碱乙酰胆碱受体的受体家族关系最密切。

Once acetylcholine receptors are bound by the antibody, they are unable to bind to acetylcholine, and therefore don't respond to the " contract" signal from the central nervous system.

一旦Ach受体与抗体结合，就无法与ACh结合，因此对中枢神经系统的“收缩”信号没有反应。

Upon arrival of neuronal impulse, synthesized acetylcholine is released into the synaptic cleft where it interacts with acetylcholine receptors located on the postsynaptic neurons.

当神经冲动到达时，合成的乙酰胆碱被释放到突触中与位于突触后神经元上的乙酰胆碱受体相互作用的裂缝。

Acetylcholinesterase degrades acetylcholine, so acetylcholinesterase inhibitors stop acetylcholinesterase from breaking down acetylcholine, which ends up increasing the concentration of acetylcholine around muscle cells and helps counteract the effects of acetylcholine receptor antibodies.

AChE水解乙酰胆碱，所以AChE抑制剂可以阻止AChE分解乙酰胆碱，从而增加肌肉细胞附近的ACh浓度，减少ACh受体抗体的影响。

Once nicotine is absorbed into the bloodstream, it binds to a type of acetylcholine receptor, called a nicotinic acetylcholine receptor - also called a nicotinic receptor - which is found throughout the body and brain.

一旦尼古丁进入血液循环，它就会和一种乙酰胆碱受体结合，也称烟碱型乙酰胆碱受体或烟碱受体；这类受体广泛分布于身体和大脑中。

So nicotine, which is in e-cigarettes, for example, binds to a receptor called the nicotinic acetylcholine receptor, which plays a key role in the functioning of almost all organ systems in the human body.

例如，电子烟中的尼古丁会与一种叫做烟碱型乙酰胆碱受体的受体结合，这种受体在人体几乎所有器官系统的功能中起着关键作用。