欧库西区，旧称欧库西-安贝诺区或欧库西-安贝诺县（德顿语：Oe-Kusi Ambenu、葡萄牙语：Oecussi-Ambeno），是东帝汶的一区，位于帝汶岛西北部，是该国一处外飞地。东、南、西为印尼的西帝汶包围，北临萨武海。面积815平方公里，人口57,469人，县域首府欧库西，下分四次区。

尽管欧库西由西帝汶与萨武海所包围，并不与东帝汶其他的国土连接，但东帝汶先前为葡萄牙的殖民地，西帝汶则为荷兰的殖民地，而欧库西却是葡萄牙到达帝汶岛时最早的根据地，因此在历史上，欧库西一直属于东帝汶的范围。

Oecusse (Tetum:Oekusi-Ambenu, also variously Oecussi, Ocussi, Oekussi, Oekusi, Okusi, Oé-Cusse), formerly Ambeno and Oecussi-Ambeno, is a district of East Timor. It is a coastal exclave in the western part of the island of Timor, separated from the rest of East Timor by West Timor, which is part of the province of Nusa Tenggara Timur, Indonesia, and which surrounds Oecusse in all directions except the north, where it borders the Savu Sea. The capital of the district is Pante Macassar, also called Oecussi Town, or formerly, in Portuguese Timor, Vila Taveiro. Originally Ambeno was the name of the district and Oecussi (< Oe Kusi) its capital.