LSD and schizophrenia
LSD is an acronym for the German chemical name Lysergsäure-Diethylamide (English: Lysergic Acid Diethylamide), a powerful semi-synthetic hallucinogen derived from the ergot fungus that infects grains of rye. Early in its history, various medical workers observed some schizophrenics had used LSD. The early work thought that LSD-induced hallucinations or psychosis resembled schizophrenic hallucinations, and "LSD psychotics" resembled schizophrenics. Surveys of schizophrenics found apparently high LSD usage rates. This led to the hypothesis that LSD is one of the causes of schizophrenia, with the mechanism being related to the serotonin neurotransmitter.