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单词 MLST
释义

MLST

中文百科

多位点串行分型 Multilocus sequence typing

(重定向自MLST)

多位点串行分型Multilocus sequence typing, MLST)是一种分子生物学分析方法。

该技术通过分析管家基因核心片段的核酸串行,对菌株的等位基因和DNA串行,进行比较性分析。多位点串行分型方法大量应用于研究不同的抗生素抵抗株、毒力或抗原的相关特殊基因型,以及新变异株引起的疾病流行病学研究。

英语百科

Multilocus sequence typing 多位点序列分型

(重定向自MLST)

Multilocus sequence typing (MLST) is a technique in molecular biology for the typing of multiple loci. The procedure characterizes isolates of microbial species using the DNA sequences of internal fragments of multiple housekeeping genes. Approximately 450-500 bp internal fragments of each gene are used, as these can be accurately sequenced on both strands using an automated DNA sequencer. For each housekeeping gene, the different sequences present within a bacterial species are assigned as distinct alleles and, for each isolate, the alleles at each of the loci define the allelic profile or sequence type (ST).

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更新时间:2025/6/23 5:08:02