Leo James Rainwater (December 9, 1917 – May 31, 1986) was an American physicist who shared the Nobel Prize in Physics in 1975 for his part in determining the asymmetrical shapes of certain atomic nuclei.

During World War II, he worked on the Manhattan Project that developed the first atomic bombs. In 1949, he began developing his theory that, contrary to what was then believed, not all atomic nuclei are spherical. His ideas were later tested and confirmed by Aage Bohr's and Ben Mottelson's experiments. He also contributed to the scientific understanding of X-rays and participated in the United States Atomic Energy Commission and naval research projects.