安条克三世（大帝）, （希腊语：Ἀντίoχoς Μέγας; 前241年－前187年, 统治期间 前223年－前187年），塞琉古二世的小儿子。前223年时，安条克三世以18岁年龄即位为塞琉古帝国第六位国王，虽然年纪轻轻就即位，但安条克三世充满雄心壮志。虽然在与托勒密王国的战争失利，但随后的争战中，安条克三世证明自己是从开国的塞琉古一世之后，历届塞琉古国王中最优秀的君主，他传统称号大帝可能是在东部征服行动结束后获得绰号，安条克三世似乎还有一个头衔Βασιλεύς Μέγας，即波斯传统称号大王的意思，可能在征服柯里叙利亚之后采用。

Antiochus III the Great (Greek: Ἀντίoχoς Μέγας; c. 241 – 187 BC, ruled 222–187 BC) was a Hellenistic Greek king and the 6th ruler of the Seleucid Empire. He ruled over the region of Syria and large parts of the rest of western Asia towards the end of the 3rd century BC. Rising to the throne at the age of eighteen in 222 BC, his early campaigns against the Ptolemaic Kingdom were unsuccessful, but in the following years Antiochus gained several military victories and substantially expanded the empire's territory. His traditional designation, the Great, reflects an epithet he assumed. He also assumed the title Basileus Megas (Greek for "Great King"), the traditional title of the Persian kings. A militarily active ruler, Antiochus restored much of the territory of the Seleucid Empire, before suffering a serious setback, towards the end of his reign, in his war against Rome.