Index case
![A 1984 paper[6] linked 40 AIDS patients by sexual contact. Of those patients, Dugas was the first to experience an onset of symptoms of AIDS. In the above graph, Dugas is represented by the circle highlighted in red.](/uploads/202501/20/AIDS_index_case_graph.svg3327.png)
The index case, primary case, or patient zero is the initial patient in the population of an epidemiological investigation, or more generally, the first case of a condition or syndrome (not necessarily contagious) to be described in the medical literature, whether or not the patient is thought to be the first person affected. An index case will sometimes achieve the status of a "classic" case in the literature, as did Phineas Gage.