组氨醇脱氢酶（英语：histidinol dehydrogenase，EC 1.1.1.23）是一种以NAD或NADP为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：

组氨醇脱氢酶也能氧化组氨醛。在细菌、真菌和植物细胞中，组氨醇脱氢酶主要负责催化组氨酸生物合成的最后一步化学反应——组氨醇的四电子氧化反应。细菌的组氨醇脱氢酶是一个单链多肽；真菌的组氨醇脱氢酶则是一个多功能酶的C端结构域，可以催化组氨酸合成过程中的3个反应；植物的组氨醇脱氢酶则是由细胞核基因编码的蛋白质前体，需被转运至叶绿体后才能发挥作用。

In enzymology, a histidinol dehydrogenase (HIS4) (HDH) (EC1.1.1.23) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are L-histidinol and NAD, whereas its 3 products are L-histidine, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is L-histidinol:NAD oxidoreductase. This enzyme is also called L-histidinol dehydrogenase.