十六进制（简写为hex或下标₁₆）在数学中是一种逢16进1的进位制。一般用数字0到9和字母A到F（或a~f）表示，其中:A~F表示10~15，这些称作十六进制数字。

例如十进制数57，在二进制写作111001，在16进制写作39。

在历史上，中国曾经在重量单位上使用过16进制，比如，规定16两为一斤。

现在的16进制则普遍应用在计算机领域，这是因为将4个比特（Bit）化成单独的16进制数字不太困难。1字节可以表示成2个连续的16进制数字。可是，这种混合表示法容易令人混淆，因此需要一些前缀、后缀或下标来显示。

In mathematics and computing, hexadecimal (also base 16, or hex) is a positional numeral system with a radix, or base, of 16. It uses sixteen distinct symbols, most often the symbols 0–9 to represent values zero to nine, and A, B, C, D, E, F (or alternatively a, b, c, d, e, f) to represent values ten to fifteen. Hexadecimal numerals are widely used by computer system designers and programmers. Several different notations are used to represent hexadecimal constants in computing languages; the prefix "0x" is widespread due to its use in Unix and C (and related operating systems and languages). Alternatively, some authors denote hexadecimal values using a suffix or subscript. For example, one could write 0x2AF3 or 2AF3₁₆, depending on the choice of notation.