全基因组关联分析 Genome-wide association study
（重定向自GWAS）
![An illustration of a Manhattan plot depicting several strongly associated risk loci. Each dot represents a SNP, with the X-axis showing genomic location and Y-axis showing association level. This example is taken from a GWA study investigating microcirculation, so the tops indicates genetic variants that more often are found in individuals with constrictions in small blood vessels.[1]](/uploads/202501/16/Manhattan_Plot1129.png)
![GWA studies typically identify common variants with small effect sizes (lower right).[7]](/uploads/202501/16/GWAS_Disease_allele_effects1129.png)
![Example calculation illustrating the methodology of a case-control GWA study. The allele count of each measured SNP is evaluated—in this case with a chi-squared test—to identify variants associated with the trait in question. The numbers in this example are taken from a 2007 study of coronary artery disease (CAD) that showed that the individuals with the G-allele of SNP1 (rs1333049) were overrepresented amongst CAD-patients.[15]](/uploads/202501/16/Method_example_for_GWA_study_designs1129.png)
![Regional association plot, showing individual SNPs in the LDL receptor region and their association to LDL-cholesterol levels. This type of plot is similar to the Manhattan plot in the lead section, but for a more limited section of the genome. The haploblock structure is visualized with colour scale and the association level is given by the left Y-axis. The dot representing the rs73015013 SNP (in the top-middle) has a high Y-axis location because this SNP explains some of the variation in LDL-cholesterol.[27]](/uploads/202501/16/Regional_Association_Plot1129.png)
全基因组关联分析（Genome-wide association study）是指在人类全基因组范围内找出存在的串行变异，即单核苷酸多态性（SNP），从中筛选出与疾病相关的SNPs。
Gwas
中文百科
英语百科
Gwas
GWAS may refer to:
| 单词 | Gwas |
| 释义 |
Gwas
中文百科
全基因组关联分析 Genome-wide association study（重定向自GWAS）
全基因组关联分析（Genome-wide association study）是指在人类全基因组范围内找出存在的串行变异，即单核苷酸多态性（SNP），从中筛选出与疾病相关的SNPs。
英语百科
GwasGWAS may refer to: |
| 随便看 |
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