Glycated hemoglobin

Glycated hemoglobin (hemoglobin A1c, HbA_1c, A1C, or Hb_1c; sometimes also referred to as being HbA1c or HGBA1C) is a form of hemoglobin that is measured primarily to identify the three month average plasma glucose concentration. The test is limited to a three month average because the lifespan of a red blood cell is three months. It is formed in a non-enzymatic glycation pathway by hemoglobin's exposure to plasma glucose. HbA_1c is a measure of the beta-N-1-deoxy fructosyl component of hemoglobin. Normal levels of glucose produce a normal amount of glycated hemoglobin. As the average amount of plasma glucose increases, the fraction of glycated hemoglobin increases in a predictable way. This serves as a marker for average blood glucose levels over the previous three months before the measurement as this is the lifespan of red blood cells.