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单词 Genetic interaction
释义

Genetic interaction

原声例句
VOA Special 2016年6月合集

Individuals with that genetic interaction, they thought, were more likely than others to get sick.

他们认为，基因进行交互作用的人更容易患病。

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Rather, it allows us to make sense of the computation being carried out by the cell in the context of genetic interactions.

相反，这能帮助我们理解在遗传相互作用的环境下细胞内在的计算程序。

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And so by translating our observations into mathematical expression in this way, it becomes possible to test whether or not those observations can emerge from a program of genetic interactions.

运用这种方法，把我们的观察值编译为一种数学表达，现在有可能测试这些观察结果是否可以从基因相互作用的程序中得到。

英语百科

Epistasis

（重定向自Genetic interaction）
The gene for total baldness is epistatic to those for blond hair or red hair. The baldness phenotype supersedes genes for hair colour and so the effects are non-additive.
Quantitative trait values after two mutations either alone (Ab and aB) or in combination (AB). Bars contained in the grey box indicate the combined trait value under different circumstances of epistasis. Upper panel indicates epistasis between beneficial mutations (blue).[5][6] Lower panel indicates epistasis between deleterious mutations (red).[7][8]
Since, on average, mutations are deleterious, random mutations to an organism cause a decline in fitness. If all mutations are additive, fitness will fall proportionally to mutation number (black line). When deleterious mutations display negative (synergistic) epistasis, they are more deleterious in combination than individually and so fitness falls with the number of mutations at an increasing rate (upper, red line). When mutations display positive (antagonistic) epistasis, effects of mutations are less severe in combination than individually and so fitness falls at a decreasing rate (lower, blue line).[7][8][9][10]
The top row indicates interactions between two genes that are either additive (a), show positive epistasis (b) or reciprocal sign epistasis (c). Below are fitness landscapes which display greater and greater levels of global epistasis between large numbers of genes. Purely additive interactions lead to a single smooth peak (d), as increasing numbers of genes exhibit epistasis, the landscape becomes more rugged (e) and when all genes interact epistatically the landscape becomes so rugged that mutations have seemingly random effects (f).

Epistasis is the phenomenon of the effect of one gene being dependent on the presence of one or more 'modifier genes', the genetic background. Thus, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them, leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes, which leads to profound consequences for evolution and evolvability of phenotype traits.
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更新时间：2025/6/17 16:55:57