So both an MYCN amplification or ALK gene fusion, where the oncogene is " turned on, " or a PHOX2B and chromosome 1 and 11 deletions, where tumor suppressor genes are " turned off, " can potentially cause uncontrolled cell growth.
因此,MYCN基因扩增或ALK基因的融合,即致癌基因被激活,或PHOX2B与1号、11号染色体缺失,即抑癌基因的失活,都可能导致细胞生长不受控制。