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单词 GABA A receptor
释义

GABA A receptor

原声例句
双语版 TED-Ed 演讲精选

Several common anesthetics bind to the GABA-A receptor in the brain's neurons.

許多常用的麻醉劑會與 大腦神經元的 GABA-A 受體結合。

科学杂志：人体健康

A number of years ago, several of my colleagues came up with a hypothesis that potentially idiopathic hypersomnia was being caused by an endogenous substance that was turning on the activity of GABA-A receptors.

多年前，我的几位同事提出了一个假设，即潜在的特发性嗜睡症是由一种内源性物质引起的，这种内源性物质会开启 GABA-A 受体的活性。

中文百科

Γ-氨基丁酸A型受体 GABAA receptor

（重定向自GABA A receptor）
GABAA 受体结构：上图: GABAA受体嵌入细胞膜的侧视图，标记有巴比妥类药物，乙醇和吸入性麻醉剂的位点。下图:视角在细胞膜外的受体俯视图，标记有GABAA受体亚基的名字，以及GABA和苯二氮䓬类药物的位点[1]
GABAA 受体的简化结构。 左图: GABAA 亚基单体嵌入磷脂双分子层。图中圆筒状物是四个跨膜α螺旋区域。N-端膜外形成半胱氨酸环的二硫键用黄线表示。 右图:五个亚基对称分布，形成中央氯离子信道。 膜外肽链未画出。
GABAA 受体蛋白的简图 图中显示五个亚基形成受体蛋白Cl-离子信道。图中有两个GABA位点，位于α1和β2亚基间，而苯二氮䓬类异构位点位于α1和γ2亚基间

GABAA受体（又称作γ-氨基丁酸A型受体）是一种离子型受体，而且是一类配体门控型离子信道。此信道的内源性配体是一种被称为GABA的神经递质。GABA是中枢神经系统里的一种主要的递质，虽然GABA在神经递质的释放过程中产生的是抑制性效应，但GABA本身并非一种抑制性而是一种刺激性递质，因为GABA激活GABA受体的开放。在GABAA受体被激活后，可以选择性的让Cl通过，引起神经元的超极化。这种超极化引起了神经信号传递抑制，因为降低了动作电位产生的成功率GABAA，在正常条件下产生的抑制性突触后电位的翻转电位是-75 mV，高于GABAB受体的-100 mV。

英语百科

GABAA receptor Γ-氨基丁酸A型受体

（重定向自GABA A receptor）
Structure of the nicotinic acetylcholine receptor (nAchR: PDB: 2BG9​) which is very similar to the GABAA receptor.[1][2][3] Top: side view of the nAchR imbedded in a cell membrane. Bottom: view of the receptor from the extracellular face of the membrane. The subunits are labeled according to the GABAA nomenclature and the approximate locations of the GABA and benzodiazepine (BZ) binding sites are noted (between the α- and β-subunits and between the α- and γ-subunits respectively).
Schematic structure of the GABAA receptor. Left: GABAA monomeric subunit imbedded in a lipid bilayer (yellow lines connected to blue spheres). The four transmembrane α-helices (1–4) are depicted as cylinders. The disulfide bond in the N-terminal extracellular domain which is characteristic of the family of cys-loop receptors (which includes the GABAA receptor) is depicted as a yellow line. Right: Five subunits symmetrically arranged about the central chloride anion conduction pore. The extracellular loops are not depicted for the sake of clarity.
Schematic diagram of a GABAA receptor protein ((α1)2(β2)2(γ2)) which illustrates the five combined subunits that form the protein, the chloride (Cl−) ion channel pore, the two GABA active binding sites at the α1 and β2 interfaces, and the benzodiazepine (BDZ) allosteric binding site[1]
GABAA 受体结构：上图: GABAA受体嵌入细胞膜的侧视图，标记有巴比妥类药物，乙醇和吸入性麻醉剂的位点。下图:视角在细胞膜外的受体俯视图，标记有GABAA受体亚基的名字，以及GABA和苯二氮䓬类药物的位点[1]

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Upon activation, the GABAA receptor selectively conducts Cl through its pore, resulting in hyperpolarization of the neuron. This causes an inhibitory effect on neurotransmission by diminishing the chance of a successful action potential occurring. The reversal potential of the GABAA-mediated IPSP in normal solution is −70 mV, contrasting the GABAB IPSP.
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更新时间：2025/6/23 2:53:39