Fluparoxan

Fluparoxan (GR50360A) (+/-)-(trans)-5-fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]benzodioxino[2,3-c]pyrrole hydrochloride hemihydrate is a potent α₂-adrenergic receptor antagonist (pK_B = 7.9) with excellent α₂/α₁ selectivity (2630 fold). It was shown to possess central α₂-adrenoceptor antagonist activity after oral doses in man and was patented as an antidepressant by Glaxo in the early 1980s, but its development was discontinued when the compound failed to show a clear clinical advantage over existing therapies.

单词	Fluparoxan
释义	Fluparoxan 英语百科 Fluparoxan Fluparoxan (GR50360A) (+/-)-(trans)-5-fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]benzodioxino[2,3-c]pyrrole hydrochloride hemihydrate is a potent α₂-adrenergic receptor antagonist (pK_B = 7.9) with excellent α₂/α₁ selectivity (2630 fold). It was shown to possess central α₂-adrenoceptor antagonist activity after oral doses in man and was patented as an antidepressant by Glaxo in the early 1980s, but its development was discontinued when the compound failed to show a clear clinical advantage over existing therapies.
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