Filaminast

Filaminast (WAY-PDA 641) was a drug candidate developed by Wyeth-Ayerst. It was a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule for several development efforts. It was discontinued after a Phase II trial showed that its therapeutic window was too narrow; it could not be dosed high enough without causing significant side effects (nausea and vomiting), which was a problem with the rolipram class of molecules.

单词	Filaminast
释义	Filaminast 英语百科 Filaminast Filaminast (WAY-PDA 641) was a drug candidate developed by Wyeth-Ayerst. It was a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule for several development efforts. It was discontinued after a Phase II trial showed that its therapeutic window was too narrow; it could not be dosed high enough without causing significant side effects (nausea and vomiting), which was a problem with the rolipram class of molecules.
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