Complement factor B

（重定向自Factor B）

Alternative pathway. (Some labels are in Polish.)

Complement factor B is a protein that in humans is encoded by the CFB gene.

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

单词	Factor B
释义	Factor B 原声例句 Linear algebra Her 1st basis factor B one points up into the right a little bit, and her 2nd vector be two points left and up. 第一个基因子B向右向上一点第二个向量向左向上两点。 CNN时尚英语精选 The primary factor, B say the study's authors: U.S. troops are subjected to multiple tours of high-intensity guerrilla warfare and face the constant threat of death or dismemberment from improvised bombs. 这份研究的作者表示，最主要的因素在于--美军参与许多高压且紧张的游击战任务，并不断面临死亡或是被土制炸弹炸断四肢的威胁。英语百科 Complement factor B （重定向自Factor B） Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
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