多巴胺β羟化酶 Dopamine beta-hydroxylase
（重定向自Dopamine beta hydroxylase）
多巴胺β羟化酶 （英语：Dopamine β-hydroxylase，简称DBH）是一种多巴胺转化为去甲肾上腺素的酶。
多巴胺β羟化酶是一个由四个相同亚基组成的290千道尔顿加氧酶，催化需维生素C作为辅因子。
Dopamine beta hydroxylase
中文百科
英语百科
Dopamine beta-hydroxylase 多巴胺β羟化酶
（重定向自Dopamine beta hydroxylase）
![Human biosynthesis pathway for trace amines and catecholamines[5][6]
L-Phenylalanine
L-Tyrosine
L-Dopa
Epinephrine
Phenethylamine
p-Tyramine
Dopamine
Norepinephrine
N-Methylphenethylamine
N-Methyltyramine
p-Octopamine
Synephrine
3-Methoxytyramine
AADC
AADC
AADC
PNMT
PNMT
PNMT
PNMT
AAAH
AAAH
COMT
DBH
DBH
In humans, catecholamines and phenethylaminergic trace amines are derived from the amino acid phenylalanine.](/uploads/202501/09/Catecholamine_and_trace_amine_biosynthesis0435.png)
Dopamine beta-hydroxylase (DBH), also known as dopamine beta-monooxygenase, is an enzyme (EC1.14.17.1) that in humans is encoded by the DBH gene. Dopamine beta-hydroxylase catalyzes the chemical reaction:
The three substrates of this enzyme are 3,4-dihydroxyphenethylamine, ascorbate, and O2, whereas its three products are noradrenaline, dehydroascorbate, and H2O.
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