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单词 Aldose reductase
释义

Aldose reductase

英语例句库

Pyridazinone derivatives have considerable kinds of biological activities such as those cardiotonic,platelet aggregation inhibitory,anti-inflammatory,aldose reductase inhibitory,antifungal and so on.

哒嗪酮类化合物具有多种重要的生物活性,根据作用机制的不同,可分为钙增敏剂、磷酸二酯酶抑制剂、环氧合酶抑制剂等,并可用于相关疾病的治疗。

The synthesis of epalrestat,an aldose reductase inhibitor, was improved. The yield of its intermediate 3-carboxymethyl rhodanine was raised to 76.4%.

对醛搪还原酶抑制剂依帕司他的合成工艺作了改进,使中间体绕丹宁乙酸的收率提高到76.4%。

中文百科

醛糖还原酶

多元醇通路
Mechanism of NADPH-dependent conversion of glucose to sorbitol. Note the hydride transfer from NADPH to the carbonyl carbon of the aldose.
Depiction of NADPH in extended confirmation and hydrogen bonded to the residues physically near the active site of the enzyme.

醛糖还原酶(aldose reductase,AR,EC1.1.1.21)存在于人体神经、红细胞、晶状体、视网膜等组织器官中,在多元醇通路中催化血液中的葡萄糖生成山梨醇。

醛糖还原酶是多元醇通路的关键限速酶。当血糖浓度维持在正常生理水平时,它并不激活,它对葡萄糖的亲和力较低,此时葡萄糖很少转化为山梨醇。在高血糖状况下(如糖尿病),己糖激酶被饱和,这时醛糖还原酶激活,促使体内的葡萄糖转化为山梨醇。然而,山梨醇脱氢酶(sorbitol dehydrogenase,SDH)的活力并未相应地成比例增加,山梨醇转化为果糖的效率没有提高。

英语百科

Aldose reductase 醛糖还原酶

Mechanism of NADPH-dependent conversion of glucose to sorbitol. Note the hydride transfer from NADPH to the carbonyl carbon of the aldose.
Depiction of NADPH in extended confirmation and hydrogen bonded to the residues physically near the active site of the enzyme.
Role of aldehyde reductase (shown in yellow box) in norepinephrine degradation, contributing in the creation of MHPG, a minor catecholamine metabolite.[6]

In enzymology, aldose reductase (or aldehyde reductase) (EC1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism.

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更新时间:2025/6/22 4:09:59