Akuammicine

Akuammicine is an alkaloid found in Vinca minor and Aspidosperma. It is a μ-opioid receptor agonists which is also agonizes (but to a much lower, clinically insignificant degree) the κ and δ-opioid receptors. Agonistic activity at both human variants of the σ-sigma receptors has been indicated but is not yet proven, so have possible mechanisms of action at the NMDA receptor (antagonist) and glycine receptor.