得梅因河（英语：Des Moines River）是密西西比河的一条支流，长约845 km（从其最长支流的源头算起）位于美国中西部。它是穿过艾奥瓦州的最大河流，源自明尼苏达州南部，从西北到东南穿过艾奥瓦州，passing from the glaciated plains into the unglaciated hills near the city of Des Moines, which takes its name from the river. It forms a short portion of Iowa's border with Missouri in Lee County. The Avenue of the Saints passes over this section.

The Des Moines River is a tributary of the Mississippi River, approximately 525 miles (845 km) long to its farther headwaters, in the upper Midwestern United States. The largest river flowing across the state of Iowa, it rises in southern Minnesota, and flows across Iowa from northwest to southeast, passing from the glaciated plains into the unglaciated hills near the city of Des Moines, which takes its name from the river. It forms a short portion of Iowa's border with Missouri in Lee County. The Avenue of the Saints passes over this section.