人格解体障碍（DPD）是精神障碍之一，它导致患者持续或反复感到人格解体或失实。诊断标准包括持续或反复的感到自己从心理过程或身体中分离出来。在DSM-IV-TR中，这一精神障碍被分类为解离症；在ICD-10中，它被称作人格解体-失实综合症，并被分类为单独一种神经质障碍对于该症的通常描述包括：感到自己从物质躯体中脱离；感到自己并未占有身体的全部；失去对自己语言、动作的控制感；觉得和自己的思想与情感断开；有一种“自动化感”——经历着生活改变，但却没有任何体验或参与感，仿佛生活是在电影里的场景；失去对身份的确定感；感到和自己的身体失去连接；觉得自己的反应不是自己故意做出的；很难把自己和现实、环境关联起来；就像是做梦一样，有灵魂出窍体验。

Depersonalization disorder (DPD), also known as depersonalization-derealization syndrome, is a mental disorder in which the people have persistent or recurrent feelings of depersonalization and/or derealization. Symptoms can be classified as either depersonalization or derealization. Depersonalization is described as feeling disconnected or estranged from one's body, thoughts, or emotions. Individuals experiencing depersonalization may report feeling as if they are in a dream or are watching themselves in a movie. They may feel like an outside observer of their own thoughts or body, and often report feeling a loss of control over their thoughts or actions. In some cases, individuals may be unable to accept their reflection as their own, or they may have out-of-body experiences. While depersonalization is a sense of detachment from one's self, derealization is described as detachment from one's surroundings. Individuals experiencing derealization may report perceiving the world around them as foggy, dreamlike/surreal, or visually distorted. In addition to these depersonalization-derealization disorder symptoms, the inner turmoil created by the disorder can result in depression, self-harm, low self-esteem, anxiety attacks, panic attacks, phobias, etc. It can also cause a variety of physical symptoms, including chest pain, blurry vision, nausea, and the sensation of pins and needles in one's arms or legs.