德米特里一世（救主）（希腊语：Δημήτριος ό Σωτηρ，？～前150年）塞琉古帝国国王（前162年～前150年在位）。

德米特里一世为塞琉古四世（笃爱父亲者）之子。他在其父在位时期一直在罗马当人质。前175年塞琉古四世去世后，其弟安条克四世（德米特里一世的叔叔）利用德米特里不在国内之机夺取了王位。然而在前162年，德米特里一世从罗马逃出，并在谋杀了他的侄子安条克五世（安条克四世之子）之后登上了江河日下的塞琉古帝国的王位。

德米特里一世的绰号“救主”是巴比伦人赠给他的，因为他帮助他们摆脱了米底亚总督提马克斯的残酷统治。提马克斯实际上是塞琉古帝国的地方官员，他利用帝国王室不断内讧之机企图创建自己的独立王国，并将军队派进了巴比伦。但是德米特里一世在前160年打败并杀死了提马克斯，使已经四分五裂的帝国暂时恢复了稳定。

Demetrius I (Greek: Δημήτριος Α`, born 185 BC, reigned 161–150 BC), surnamed Soter (Greek: Σωτήρ - "Savior"), was a ruler of the Hellenistic Seleucid Empire.

Demetrius was sent to Rome as a hostage during the reign of his father Seleucus IV Philopator and his mother Laodice IV. When his father was murdered by his finance minister Heliodorus in 175 BC., his uncle Antiochus IV Epiphanes killed the usurper, but usurped the throne himself. When Antiochus IV died in 163 BC., his 9-year-old boy son Antiochus V Eupator was made king by Lysias. Demetrius was then 22 years old (thus he was born in 185 BC). He requested the Roman Senate to restore the Syrian throne to him, but was rejected, since the Romans believed that Syria should be ruled by a boy rather than a man. Two years later, Antiochus V was greatly weakened because Rome sent an emissary to sink his ships and hamstring his elephants for his violation of the Peace of Apamea, storing up too much weaponry. Demetrius escaped from confinement and was welcomed back on the Syrian throne in 161 BC. He immediately killed Antiochus V and Lysias.