Demethylase

Top: FAD-dependent amine oxidase mechanism of lysine demethylation Bottom: Fe(II) and α-ketoglutarate-dependent dioxygenase

Structure of JmJDA (coordinates from PDB file:2UXX); Some domains from above are highlighted: JmJ(N-terminus, red; C-terminus, yellow), Zinc finger domain (light purple), Beta-hairpin (light blue), and mixed domain linker (green).

Structure of KDM1A (coordinates from PDB file:2Z5U)

Cartoon representation of the molecular structure of protein registered with 1A2O pdb code.

Demethylases are enzymes that remove methyl (CH₃-) groups from nucleic acids, proteins (in particular histones), and other molecules. Demethylase enzymes are important in epigenetic modification mechanisms. The demethylase proteins alter transcriptional regulation of the genome by controlling the methylation levels that occur on DNA and histones and, in turn, regulate the chromatin state at specific gene loci within organisms.

单词	Demethylase
释义	Demethylase 英语百科 Demethylase Demethylases are enzymes that remove methyl (CH₃-) groups from nucleic acids, proteins (in particular histones), and other molecules. Demethylase enzymes are important in epigenetic modification mechanisms. The demethylase proteins alter transcriptional regulation of the genome by controlling the methylation levels that occur on DNA and histones and, in turn, regulate the chromatin state at specific gene loci within organisms.
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