Cutaneous myxoma

A cutaneous myxoma, AKA superficial angiomyxoma, consists of a multilobulated myxoid mass containing stellate and/or spindled fibroblasts with pools of mucin forming cleft-like spaces. There is often a proliferation of blood vessels and an inflammatory infiltrate. Staining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, SMA, MSA and S-100.