伊利沙伯线（英语：Elizabeth line），工程代号为横贯铁路（Crossrail）是英国伦敦一条建筑中的客运铁路，它将横贯首都中央地区与主要伦敦地铁站交汇并伸展到大伦敦以外东西两则的市郊地区及希斯洛机场。经历数十年的筹划后铁路于2009年动工，这是同时期欧洲内规模最大的铁路基建项目，工程主要集中于路线贯穿市中心的部分。计划的目标是提供频密的通勤和市郊与市中心接驳铁路服务。

除了与其他铁路共用既有路轨外，伊利沙伯线新建的部分是由帕丁顿车站贯穿首都市中心至史特拉福站的42公里专用隧道，及从白教堂站向东伸延至泰晤士河以南的修道院森林车站的支线。

Crossrail is a 118-kilometre (73-mile) railway line under development in London and the home counties of Berkshire, Buckinghamshire and Essex. The central section and a large portion of the line, between Paddington in central London and Abbey Wood in the south-east, are due to open in December 2018; at that time the service will be named the Elizabeth line. The western section beyond Paddington, to Reading in Berkshire and Heathrow Airport, is due to enter operation in December 2019, completing the new east-west route across Greater London. Part of the eastern section, between Liverpool Street and Shenfield in Essex, transferred to a precursor service called TfL Rail in 2015; this section will be connected to the central route through central London to Paddington in May 2019.