皮质类固醇（英语：Corticosteroids）是由肾上腺皮质制造和分泌的类固醇激素，也可经由人工合成。它的药理作用复杂，且广泛涉及生理系统作用，如压力反应、免疫反应，以及发炎、糖类代谢作用、蛋白质分解代谢、血液中电解质浓度等的控制。皮质类固醇主要分为二类：

人体内普遍存在的天然激素包括：皮质酮（C₂₁H₃₀O₄）、可的松（C₂₁H₂₈O₅，17-羟-11脱氢皮质(甾)酮）和醛固酮。

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Corticosteroids are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.