Conjugate vaccine

A conjugate vaccine is created by covalently attaching a poor (polysaccharide) antigen to a carrier protein (preferably from the same microorganism), thereby conferring the immunological attributes of the carrier to the attached antigen.

B cell response to a capsular polysaccharide is T cell independent, meaning that B cells can produce antibodies without T cell stimulation. By conjugating the polysaccharide to a protein carrier, a T cell response can be induced. Normally, polysaccharides by themselves cannot be loaded onto the MHC complex of antigen presenting cells (APC) because MHC can only bind peptides. In the case of a conjugate vaccine, the carrier peptide linked to the polysaccharide target antigen is able to be presented on the MHC molecule and the T cell can be activated. T cells stimulate a more vigorous immune response and also promote a more rapid and long-lasting immunologic memory. This technique for the creation of an effective immunogen is most often applied to bacterial polysaccharides for the prevention of invasive bacterial disease.

单词	Conjugate vaccine
释义	Conjugate vaccine 原声例句当月 VOA Special English Officials suggest that all children should get a " meningococcal conjugate vaccine" around the age of 11. 官方建议所有儿童在11岁左右接种“脑膜炎球菌结合疫苗”。精选英语短文 Conjugate vaccines, however, are made using pieces from the coats of bacteria. 然而，结合疫苗是使用细菌外壳的碎片制成的。精选英语短文 Conjugate vaccines are somewhat similar to recombinant vaccines: they're made using a combination of two different components. 结合疫苗与重组疫苗有些相似：它们是使用两种不同成分的组合制成的。精选英语短文 Both subunit and conjugate vaccines contain only pieces of the pathogens they protect against. 亚单位疫苗和结合疫苗都只包含它们可以抵御的病原体片段。精选英语短文 Conjugate vaccines are used to create a more powerful, combined immune response: typically the " piece" of bacteria being presented would not generate a strong immune response on its own, while the carrier protein would. 结合疫苗用于产生更强大的联合免疫反应：通常，所呈现的细菌“片段” 本身不会产生强烈的免疫反应，而载体蛋白会。英语百科 Conjugate vaccine A conjugate vaccine is created by covalently attaching a poor (polysaccharide) antigen to a carrier protein (preferably from the same microorganism), thereby conferring the immunological attributes of the carrier to the attached antigen. B cell response to a capsular polysaccharide is T cell independent, meaning that B cells can produce antibodies without T cell stimulation. By conjugating the polysaccharide to a protein carrier, a T cell response can be induced. Normally, polysaccharides by themselves cannot be loaded onto the MHC complex of antigen presenting cells (APC) because MHC can only bind peptides. In the case of a conjugate vaccine, the carrier peptide linked to the polysaccharide target antigen is able to be presented on the MHC molecule and the T cell can be activated. T cells stimulate a more vigorous immune response and also promote a more rapid and long-lasting immunologic memory. This technique for the creation of an effective immunogen is most often applied to bacterial polysaccharides for the prevention of invasive bacterial disease.
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