牟比士症候群（Möbius syndrome，或拼做Moebius）是一个很罕见的遗传性神经失调疾病，明显的特征是颜面神经麻痹以及没办法控制眼球的移动。大部分刚出生患有牟比士症候群的人都伴随着完全的颜面神经瘫痪，也就是他们没办法闭上眼睛或是在脸上产生表情。四肢和胸腔发育不正常的特征，有时候也会跟着这疾病出现。多数患有牟比士症候群的人智力都是正常的，一般大众不需要为他们呆滞且不友善的表情感到困惑。这疾病的名称取名自神经学家保罗·朱力曼尼·牟比士，他在1888年首次陈述这个疾病。

Möbius syndrome (also spelled Moebius) is an extremely rare congenital neurological disorder which is characterized by facial paralysis and the inability to move the eyes from side to side. Most people with Möbius syndrome are born with complete facial paralysis and cannot close their eyes or form facial expressions. Limb and chest wall abnormalities sometimes occur with the syndrome. People with Möbius syndrome have normal intelligence, although their lack of facial expression is sometimes incorrectly taken to be due to dullness or unfriendliness. It is named for Paul Julius Möbius, a neurologist who first described the syndrome in 1888.