Combes喹啉合成
![R1, R2 und R3 sind Alkyl- oder Arylreste die gleich oder verschieden sein können.[2]](/uploads/202501/05/Combes-Chinolinsynthese_Ü-v1.svg1018.png)
Combes喹啉合成（Combes quinoline synthesis）
伯芳胺与β-二酮在酸催化下缩合为亚胺，然后关环，生成喹啉的衍生物。
- Conrad-Limpach反应
- Doebner反应
- Doebner-Miller反应
- 化学反应列表
Combes quinoline synthesis
中文百科
英语百科
Combes quinoline synthesis Combes喹啉合成
The Combes quinoline synthesis is a chemical reaction, which was first reported by Combes in 1888. It involves the condensation of unsubstituted anilines (1) with β-diketones (2) to form substituted quinolines (4) after an acid-catalyzed ring closure of an intermediate Schiff base (3). Further studies and reviews of the Combes quinoline synthesis and its variations have been published by Alyamkina et al., Bergstrom and Franklin, Born, and Johnson and Mathews.
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